Furthermore, increased sensitivity to radiation induced cancer in the inherited condition Mre11h resulting in the inability to fix DNA double-strand breaks.
2.
Later, their immune systems weaken, respiratory infections are frequent and there is a profound sensitivity to radiation, such as X-rays.
3.
Ataxia telangiectasia ( AT ) is a rare human disease characterized by cerebellar degeneration, extreme cellular sensitivity to radiation and a predisposition to cancer.
4.
In addition, Collins said, scientists have used yeast genes to figure out the function of a human gene, ataxia telangiectasia, that when mutated leads to a susceptibility to cancer and to extreme sensitivity to radiation damage.
5.
Two adult siblings, both heterozygous for two particular " NBS1 " nonsense mutations displayed cellular sensitivity to radiation, chromosome instability and fertility defects, but not the developmental defects that are typically found in other NBS patients.
6.
Like those with A-T, children with NBS have enhanced sensitivity to radiation, disposition to lymphoma and leukemia, and some laboratory measures of impaired immune function, but do not have ocular telangiectasia or an elevated level of AFP.
7.
Now that the A-T gene has been isolated, researchers are trying to develop a screening test for carriers _ all the more urgent, since ATM causes extreme sensitivity to radiation in X-rays and some cancer treatments, Gatti said.
8.
A sharp, puzzling increase in cancer risk among women under 20 at the time may indicate that a subgroup of the population had an abnormal sensitivity to radiation, or perhaps indicates the effect of familial breast cancer genes, or an interaction between such a gene and radiation, said Land.
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